NIH awards UGA researchers $2.6 million to fight African sleeping sickness

Posted 6 months 2 days ago
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The National Institutes of Health has awarded $2.6 million to University of Georgia researchers to develop new drugs to treat human African Trypanosomiasis, also known as African sleeping sickness:

African Trypanosomiasis, commonly known as HAT, is caused by a single-celled parasite called Trypanosoma brucei, which is transmitted to humans through the bite of a blood-sucking insect called a tsetse fly.

Following a bite, the parasite multiplies in subcutaneous tissues and eventually crosses the blood-brain barrier to infect the central nervous system, causing changes in...

Progress against infectious diseases continues

Posted 8 months 2 weeks ago
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Scientists' fight against cryptosporidiosis recently reached a major milestone:

Infectious disease scientists from research institutions including the University of Georgia have reported the discovery and early validation of a drug that shows promise for treating cryptosporidiosis, a diarrheal disease that is a major cause of child mortality and for which there is no vaccine or effective treatment.

"Cryptosporidiosis is largely a disease of poverty," said Boris Striepen, Distinguished Research Professor of Cellular Biology in UGA's Franklin College of Arts and Sciences and a...

Researchers publish breakthrough in reversing leukemia

Posted 9 months 1 week ago
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Today in the journal Nature, a UGA research team led by Takahiro Ito published important new work that identifies a new drug target for the two most common types of myeloid leukemia, including a way to turn back the most aggressive form of the disease:

By blocking a protein called BCAT1, the researchers were able to stop cancer cell growth in mice and human blood samples from leukemia patients.

The BCAT1 protein activates the metabolism of a group of amino acids known as branched-chain amino acids, or BCAAs, that are essential building blocks of proteins in all cells and thus...

Center for Molecular Medicine

Posted 1 year 1 week ago
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Progress on the new 43,000-square-foot research facility, which will host teams of scientists working to uncover new treatments for such maladies as obesity, cardiovascular disease, diabetes and neurological disorders, continues apace:

"The research emphasis of the center is to study different aspects of human disease and use that information to develop therapeutics and diagnostics," said Stephen Dalton, director of the center and a GRA Eminent Scholar of Molecular Cell Biology. 

Researchers will explore diseases at the molecular level to understand the effects of drugs and...

$2.78 million from NIH to study CRISPR-Cas

Posted 1 year 2 months ago
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One of the most promising technologies in at least a generation, CRISPR-Cas is a powerful gene editing tool derived from a defense mechanism evolved in bacteria and other single-celled organisms. Progress on the tool at UGA will continue thanks to a new grant from the National Institutes of Health:

CRISPR-Cas allows scientists to precisely edit sequences of DNA in everything from plants to humans, and it could one day be used to silence the genes that predispose humans to myriad diseases, including cancer, diabetes, cardiovascular disorders and mental illnesses.

"This is a...