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Triple Franklin major Stephan George (B.S. Biochemistry and Molecular Biology; B.S. Genetics; B.S. Biology) is committed to making a difference for people with disabilities: I am currently conducting a research project in the Wells laboratory at the Complex Carbohydrate Research Center. I am investigating the role that seven mutations in a gene called O-GlcNAc Transferase play in the development of intellectual disability. I also recently…
Today in the journal Nature, a UGA research team led by Takahiro Ito published important new work that identifies a new drug target for the two most common types of myeloid leukemia, including a way to turn back the most aggressive form of the disease: By blocking a protein called BCAT1, the researchers were able to stop cancer cell growth in mice and human blood samples from leukemia patients. The BCAT1 protein activates the metabolism of a…
Genetics researchers share a new study that builds on 50 years of theorizing by behavioralists - how parenting changes parents: The study, published this month in Nature Communications, finds that the transition from a non-parenting state to a parenting state reflects differences in neuropeptides generally associated with mating, feeding, aggression and increased social tolerance. Neuropeptides are small proteins that allow neurons in…
A $1.3 million grant from the Gordon and Betty Moore Foundation will allow Franklin researchers to uncover answers about an important metabolic link that takes place in the Earth's oceans: Microorganisms in the largest microbial habitat on Earth, the ocean microbiome, function similarly to microorganisms in the human gut; they perform chemical transformations that keep the whole system healthy. Phytoplankton, the microbial primary producers of…
Edison is the third GRA Eminent Scholar to join UGA this year. He brings the total number of GRA scholars at UGA to 17. Among the brightest minds in their fields, eminent scholars also represent a driver of Georgia's technology-rich economic development strategy. Working on breakthroughs in science and technology, their work is a leverage on expertise that makes interdisciplinary entities like the CCRC or the Center for Molecular Medicine…
A new paper by research scientists at the Complex Carbohydrate Research Center focuses on cancer stem cells: the research team demonstrates that the sugar molecule, made by an enzyme known as GnT-V, regulates the development of a particular subset of cancerous cells known as cancer stem cells. Much like normal stem cells that sustain organs and tissues, cancer stem cells can self-renew, and their cellular offspring clump together to form tumors…
Complex carbohydrates are the key to cell behavior, and the ability to study them at UGA and train the next generation of researchers just received a great boost: University of Georgia researchers have received a five-year $850,000 grant from the National Institutes of Health to establish a glycoscience training program for pre-doctoral graduate students that will help train a new generation of carbohydrate researchers. The award makes UGA one…
While they are often identified as poles, a spectrum or even a line of demarcation from one kind of investigation into another, science and art can and occasionally do cohabitate, as in the case of UGA research scientist Stefan Eberhard, who utilizes scientific instrumentation for creative purposes: Besides being a longtime research professional at the University of Georgia’s Complex Carbohydrate Research Center, Eberhard is also an accomplished…
Startling new discovery of a gene that may play an important role in the development of the life-threatening birth defect congenital diaphragmatic hernia, or CDH: The hallmark of CDH is a rupture of the diaphragm that allows organs found in the lower abdomen, such as the liver, spleen and intestines, to push their way into the chest cavity. The invading organs crowd the limited space and can lead to abnormal lung development or poor lung…
Glycobiology is very complex science - the study the structures, biosynthesis and biology of the sugar chains, or glycans, that are essential components in all living things. Glycans have been the focus of much attention by UGA researchers recently, and now glycobiology is at the center of big new NIH grant to another team of Franklin College researchers: Researchers at the University of Georgia have received a five-year, $10.4 million grant…
Researchers at the Complex Carbohydrate Research Center announced a new methodology with broad implications for human health. A research team led by Geert-Jan Boons, Franklin Professor in the department of chemistry, recently published on the first method for synthesizing asymmetrical N-glycans: According to the study, published in the journal Science on July 25, the approach could lead to a better understanding of how viruses and bacteria enter…
Great new work from Debra Mohnen and Li Tan in the BioEnergy Science Center: When Li Tan approached his colleagues at the University of Georgia with some unusual data he had collected, they initially seemed convinced that his experiment had become contaminated; what he was seeing simply didn’t make any sense. Tan was examining some of the sugars, proteins and polymers that make up plant cell walls, which provide the structural support and…
More terrific news from Franklin College scientists in the CCRC: Ovarian and pancreatic cancers are among the most deadly, not because they are impossible to cure, but because they are difficult to find. There are no screening tests that can reliably detect their presence in early stages, and most diagnoses are made after the disease has already spread to lymph nodes and vital organs. But University of Georgia cancer researchers Karen Abbott and…
New changes in molecular structures on the surface of stem cells, recently discovered by UGA researchers, may play a critical role in the specialization process of embryonic growth: Their study, published recently in the Journal of Biological Chemistry, demonstrated how the genetic expression of specific enzymes resulted in significant changes to the complex chains of sugar molecules that densely coat the outside of cells. Known as glycans,…

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